何創(chuàng)龍教授
何創(chuàng)龍，教授，博士生導師。現(xiàn)任東華大學生物與醫(yī)學工程學院副院長，東華大學生物制造與組織再生課題組負責人。2004年獲重慶大學生物醫(yī)學工程專業(yè)博士學位，并先后在同濟大學和美國密歇根大學進行博士后研究。主要從事生物材料和組織工程等領(lǐng)域的研究。先后主持科技部重點研發(fā)計劃、國家自然科學基金等科研項目30多項；在Advanced Materials、Advanced Functional Materials、ACS Nano、等學術(shù)期刊上發(fā)表論文230多篇；獲授權(quán)國家發(fā)明專利35項；先后入選Elsevier“中國高被引學者”榜單、斯坦福大學發(fā)布全球前2%頂尖科學家榜單年度科學影響力排行榜和“終身科學影響力排行榜”。擔任期刊Composites part B: Engineering助理編輯、Smart Materials in Medicine編委和ACS Biomaterials Science & Engineering顧問編委。
研究方向：
1、 骨、軟骨、關(guān)節(jié)、血管、創(chuàng)面修復材料
2、 生物打印與人體類器官
3、 骨和關(guān)節(jié)疾病診療材料與技術(shù)
4、 可穿戴智能材料與器件
榮譽及獲獎情況：
1、 第三屆全國大學生生命科學競賽指導教師一等獎（2019年）
2、 上海市第一屆大學生生命科學競賽特等獎（指導教師）（2019年）
3、 香港桑麻基金會桑麻獎教金（2018年）
4、 第三屆全國大學生生命科學創(chuàng)新創(chuàng)業(yè)大賽指導教師一等獎（2018年）
5、 上海市科學技術(shù)獎自然科學三等獎（2015年）
近年來承擔的主要科研項目：
1、 國家重點研發(fā)計劃（2022YFC2403000），2022.11-2025.10，課題骨干，在研。
2、 國家重點研發(fā)計劃（2018YFB1105600），2018.5-2021.4，課題主持，結(jié)題。
3、 國家自然科學基金面上項目（32271412），2023.1-2026.12，主持，在研。
4、 國家自然科學基金面上項目（32071350），2021.1-2024.12，主持，在研。
5、 國家自然科學基金面上項目（31771048），2018.1-2021.12，主持，結(jié)題。
6、 國家自然科學基金面上項目（31570984），2016.1-2019.12，主持，結(jié)題。
7、 國家自然科學基金面上項目（31271028），2013.1-2016.12，主持，結(jié)題。
近年來發(fā)表的代表性論著、專利：
論文
1、 Feng Q, Fatima K, Yang A, Li CL, Chen S, Yang G, Zhou XJ*, He CL*. Multi-modal imaging for dynamic visualization of osteogenesis and implant degradation in 3D bioprinted scaffolds. Bioactive Materials, 2024, 119-131.
2、Yang A, Wang Y, Feng Q, Fatima K, Zhang QQ, Zhou XJ*, He CL*. Integrating fluorescence and magnetic resonance imaging in biocompatible scaffold for real-time bone repair monitoring and assessment. Advanced Healthcare Materials, 2024, 13(6): 2302687.
3、Lu ZY, Du S, Li JX, Zhang M, Nie HL, Zhou XJ, Li FL, Wei XW, Wang JQ, Liu FY, He CL*, Yang G*, Gu Z*. Langmuir-Blodgett-mediated formation of antibacterial microneedles for long-term transdermal drug delivery. Advanced Materials, 2023, 35: 2303388.
4、Guo ST, He CL*. Bioprinted scaffold remodels the neuromodulatory microenvironment for enhancing bone regeneration, Advanced Functional Materials, 2023, 2304172.
5、Zhou XJ, Qian YH, Chen L, Li T, Sun X, Ma XJ*, Wang JW*, He CL*. Flowerbed-inspired biomimetic scaffold with rapid internal tissue infiltration and vascularization capacity for bone repair. ACS Nano, 2023, 17(5): 5140-5156.
6、Shi TT, Lu HZ, Zhu JY, Zhou XJ, He CL*, Li FL*, Yang G*. Naturally derived dual dynamic crosslinked multifunctional hydrogel for diabetic wound healing. Composites Part B: Engineering, 2023, 257: 110687.
7、Sun X, Yang J, Ma J, Wang TC, Zhao X, Zhu D, Jin WJ, Zhang K, Sun XZ, Shen YL, Xie N, Yang F, Li S, Zhou XJ, He CL*, Zhang DT*, Wang JW*. Three-dimensional bioprinted BMSCs-laden highly adhesive artificial periosteum containing gelatin-dopamine and graphene oxide nanosheets promoting bone defect repair. Biofabrication, 2023, 15(2): 025010.
8、Fu LW, Feng Q, Chen YJ, Fu JZ, Zhou XJ, He CL*. Nanofibers for the immunoregulation in biomedical applications. Advanced Fiber Materials, 2022, 4:1334-1356.
9、Nie W, Dai XY, Copus JS, Kengla K, Xie RY, Seeds M, Atala A*, He CL*. Rapid mineralization of graphene-based 3D porous scaffolds by semi-dry electrodeposition for photothermal treatment of tumor-induced bone defects. Acta Biomaterialia, 2022, 153: 573-584.
10、Li SK, Li ZH, Yang J, Ha YJ, Zhou XJ*, He CL*. Inhibition of sympathetic activation by delivering calcium channel blockers from a 3D printed scaffold to promote bone defect repair. Advanced Healthcare Materials,2022, 11(16): 2200785.
11、Li ZH, Li SK, Yang J, Ha YJ, Zhang QQ, Zhou XJ*, He CL*. 3D bioprinted gelatin/gellan gum-based scaffold with double-crosslinking network for vascularized bone regeneration.Carbohydrate Polymers, 2022, 290: 119469.
12、Ha YJ, Ma XJ, Li SK, Li T, Li ZH, Qian YH, Shafiq M, Wang JW, Zhou XJ*, He CL*. Bone microenvironment-mimetic scaffolds with hierarchical microstructure for enhanced vascularization and bone regeneration, Advanced Functional Materials, 2022, 32, 2200011.
13、Fu LW, Zhang WY, Zhou XJ, Fu JZ*, He CL*. Tumor cell membrane -camouflaged responsive nanoparticles enable MRI-guided immuno-chemodynamic therapy of orthotopic osteosarcoma.Bioactive Materials,2022, 17: 221-233.
14、Gu JN, Zhang QQ, Geng MR, Wang WZ, Yang J, Atta ur Rehman Khan, Du HB, Sha Z, Zhou XJ*, He CL*. Construction of nanofibrous scaffolds with interconnected perfusable microchannel networks for engineering of vascularized bone tissue. Bioactive Materials, 2021, 6(10): 3254-3268.
15、Chai NW, Zhang JT, Zhang QQ, Du HB, He X, Yang J, Zhou XJ*, He JW*, He CL*. Construction of 3D printed constructs based on microfluidic microgel for bone regeneration. Composites Part B: Engineering, 2021, 223: 109100.
16、Xue S, Zhou XJ, Shan WL, Wang C, Lu HM, Xu YM, Zhong YM, Zhu LB*, He CL*, Ma JZ*. Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy.Bioactive Materials, 2021, 6(8): 2372-2389.
17、Cai JY, Zhang QQ, Chen JB, Jiang J, Mo XM, He CL*, Zhao JZ*. Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction. Bioactive Materials, 2021, 6(3): 783-793.
18、He X, Liu XZ, Yang J, Du HB, Chai NW, Sha Z, Geng MR, Zhou XJ*, He CL*. Tannic acid-reinforced methacrylated chitosan/methacrylated silk fibroin hydrogels with multifunctionality for accelerating wound healing. Carbohydrate Polymers, 2020, 247: 116689.
19、Yang SG, Chen L, Zhou XJ, Sun P, Fu LW, You YL, Xu M, You ZW, Kai GY*, He CL*. Tumor-targeted biodegradable multifunctional nanoparticles for cancer theranostics.Chemical Engineering Journal, 2019, 378: 122171.
20、 Liu DH, Nie W, Li DJ, Wang WZ, Zheng LX, Zhang JT, Zhang JL, Peng C, Mo XM, He CL*. 3D printed PCL/SrHA scaffold for enhanced bone regeneration. Chemical Engineering Journal, 2019, 362: 269-279.
21、Chen L, Zhang JL, Zhou XJ, Yang SG, Zhang QQ, Wang WZ, You ZW, Peng C*, He CL*. Merging metal organic framework with hollow organosilica nanoparticles as versatile nanoplatform for cancer theranostics. Acta Biomaterialia, 2019, 86: 406-415.
22、Wang WZ, Nie W, Zhou XJ, Feng W, Chen L, Zhang QQ, You ZW, Shi QS*, Peng C*, He CL*. Fabrication of heterogeneous porous bilayered nanofibrous vascular grafts by two-step phase separation technique. Acta Biomaterialia, 2018, 79: 168-181.
23、Chen L, Zhou XJ, Nie W, Feng W, Zhang QQ, Wang WZ, Zhang YZ, Chen ZG, Huang P*, He CL*. Marriage of albumin-gadolinium complexes and MoS2 nanoflakes as cancer theranostics for dual-modality magnetic resonance/photoacoustic imaging and photothermal therapy. ACS Applied Materials & Interfaces, 2017, 9 (21): 17786-17798.
24、Chen L, Feng YH, Zhou XJ, Zhang QQ, Nie W, Wang WZ, Zhang YZ, He CL*. One-pot synthesis of MoS2 nanoflakes with desirable degradability for photothermal cancer therapy. ACS Applied Materials & Interfaces, 2017, 9 (20): 17347-17358.
25、Nie W, Peng C, Zhou XJ, Chen L, Wang WZ, Zhang YZ, Ma PX*, He CL*. Three-dimensional porous scaffold by self-assembly of reduced graphene oxide and nano-hydroxyapatite composites for bone tissue engineering. Carbon, 2017, 126: 325-337.
26、Chen L, Zhou XJ, Nie W, Zhang QQ, Wang WZ, Zhang YZ, He CL*. Multifunctional redox-responsive mesoporous silica nanoparticles for efficient targeting drug delivery and magnetic resonance imaging. ACS Applied Materials & Interfaces, 2016, 8 (49): 33829-33841.
27、Qiu KX, Chen B, Nie W, Zhou XJ, Feng W, Wang WZ, Chen L, Mo XM, Wei YZ, He CL*. Electrophoretic deposition of dexamethasone-loaded mesoporous silica nanoparticles onto poly(L-lactic acid)/poly(ε–caprolactone) composite scaffold for bone tissue engineering. ACS Applied Materials & Interfaces, 2016, 8 (6): 4137-4148.
28、 Zhou XJ, Feng W, Qiu KX, Chen L, Wang WZ, Nie W, Mo XM, He CL*. BMP-2 derived peptide and dexamethasone incorporated mesoporous silica nanoparticles for enhanced osteogenic differentiation of bone mesenchymal stem cells. ACS Applied Materials & Interfaces, 2015, 7 (29): 15777-15789.
29、Feng W, Zhou XJ, Nie W, Chen L, Qiu KX, Zhang YZ, He CL*. Au/ polypyrrole@Fe3O4 nanocomposites for MR/CT dual-modal imaging guided- photothermal therapy: an in vitro study. ACS Applied Materials & Interfaces, 2015, 7(7): 4354-4367.
30、Feng W, Nie W, He CL*, Zhou XJ, Chen L, Qiu KX, Wang WZ, Yin ZQ. Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers. ACS Applied Materials & Interfaces, 2014, 6 (11): 8447-8460.
31、He CL, Jin XB, Ma PX. Calcium phosphate deposition rate, structure and osteoconductivity on electrospun poly(l-lactic acid) matrix using electrodeposition or simulated body fluid incubation. Acta Biomaterialia, 2014, 10(1): 419-427.
32、He CL, Xiao GY, Jin XB, Sun CH, Ma PX. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography. Advanced Functional Materials, 2010, 20(20): 3568-3576.
主要學術(shù)兼職：
1、 中國生物材料學會理事兼骨修復材料與器械分會副主任委員
2、 中國解剖學會血管分會副主任委員
3、 上海市生物與學工程學會生物材料專業(yè)委員會副主任委員
個人學術(shù)主頁：
https://orcid.org/0000-0001-8330-8542；
https://www.scopus.com/authid/detail.uri?authorId=13003729900
聯(lián)系電話： 021-67792666 E-MAIL：hcl@dhu.edu.cn
